TCF7L2 regulates pancreatic β-cell function through PI3K/AKT signal pathway
نویسندگان
چکیده
منابع مشابه
MicroRNA-7a regulates pancreatic β cell function.
Dysfunctional microRNA (miRNA) networks contribute to inappropriate responses following pathological stress and are the underlying cause of several disease conditions. In pancreatic β cells, miRNAs have been largely unstudied and little is known about how specific miRNAs regulate glucose-stimulated insulin secretion (GSIS) or impact the adaptation of β cell function to metabolic stress. In this...
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متن کاملSelective disruption of Tcf7l2 in the pancreatic β cell impairs secretory function and lowers β cell mass
Type 2 diabetes (T2D) is characterized by β cell dysfunction and loss. Single nucleotide polymorphisms in the T-cell factor 7-like 2 (TCF7L2) gene, associated with T2D by genome-wide association studies, lead to impaired β cell function. While deletion of the homologous murine Tcf7l2 gene throughout the developing pancreas leads to impaired glucose tolerance, deletion in the β cell in adult mic...
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Proliferation of pancreatic β-cells is an important mechanism underlying β-cell mass adaptation to metabolic demands. Increasing β-cell mass by regeneration may ameliorate or correct both type 1 and type 2 diabetes, which both result from inadequate production of insulin by β-cells of the pancreatic islet. Transforming growth factor β (TGF-β) signaling is essential for fetal development and gro...
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ژورنال
عنوان ژورنال: Diabetology & Metabolic Syndrome
سال: 2019
ISSN: 1758-5996
DOI: 10.1186/s13098-019-0449-3